MBGE SEMINAR by Idil Orhon

The kidney consists of different segments that are essential in maintaining homeostasis throughout the body, including regulating electrolyte and water balance. The last segment of the kidney tubules is called the collecting duct (CD), where finetuning of sodium and water reabsorption occurs. A dysfunction of this process can lead to nephrogenic diabetes insipidus (NDI) that causes the inability to concentrate urine which can lead to patients excreting urine from 3 to 20 liters per day with risk of severe dehydration. It is known that NDI is caused by dysfunction of the water channel aquaporin 2 (AQP2) or the vasopressin 2 receptor (V2R) in the CD. Despite promising results of pre-clinical experiments, clinical trials often fail due to ineffectiveness or side-effects...

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